The relationship between Cognitive Reserve and Math Abilities

Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the different degree of impairment in cognitive abilities in aging. The aim of this study is to verify the effect of Cognitive Reserve, as measured by a questionnaire, on a variety of numerical abilities (number comprehension, reading and writing numbers, rules and principles, mental calculations and written calculations), in a group of healthy older people (aged 65-98 years). Sixty older individuals were interviewed with the Cognitive Reserve Index questionnaire (CRIq), and assessed with the Numerical Activities of Daily Living battery (NADL), which included formal tasks on math abilities, an informal test on math, one interview with the participant, and one interview with a relative on the perceived math abilities. We also took into account the years of education, as another proxy for Cognitive Reserve. In the multiple regression analyses on all formal tests, CRIq scores did not significantly predict math performance. Other variables, i.e., years of education and Mini-Mental State Examination score, accounted better for math performance on NADL. Only a subsection of CRIq, CRIq-Working-activity, was found to predict performance on a NADL subtest assessing informal use of math in daily life. These results show that education might better explain abstract math functions in late life than other aspects related to Cognitive Reserve, such as lifestyle or occupational attainment

Numerical Activities and Information Learned at Home Link to the Exact Numeracy Skills in 5-6 Years-Old Children

It is currently accepted that certain activities within the family environment contribute to develop early numerical skills before schooling. However, it is unknown whether this early experience influences both the exact and the approximate representation of numbers, and if so, which is more important for numerical tasks. In the present study the mathematical performance of 110 children (mean age 5 years 11 months) was evaluated using a battery that included tests of approximate and exact numerical abilities, as well as everyday numerical problems. Moreover, children were assessed on their knowledge of number information learned at home. The parents of the participants provided information regarding daily activities of the children and socio-demographic characteristics of the family. The results showed that the amount of numerical information learned at home was a significant predictor of participants' performance on everyday numerical problems and exact number representations, even after taking account of age, memory span and socio-economic and educational status of the family. We also found that particular activities, such as board games, correlate with the children's counting skills, which are foundational for arithmetic. Crucially, tests relying on approximate representations were not predicted by the numerical knowledge acquired at home. The present research supports claims about the importance and nature of home experiences in the child's acquisition of mathematics

Lexical categories or frequency effects? A feedback from quantitative methods applied to psycholinguistic models in two studies on Italian

Abstract English. We examined two issues concerning Italian Number morphology: the phenomena related to mass and count nouns and to the plural dominance. By taking into account quantitative data from corpora and subjective frequency ratings in three mixed effect models, we found that differences in participants' performance in two lexical decision tasks could be better captured as differences in frequency rather than in terms of effects of lexical categories. Italiano. In questo studio sono stati posti a confronto due fenomeni pertinenti alla morfologia nominale di Numero in italiano: la contabilità dei nomi e la dominanza plurale. Integrando i dati quantitativi provenienti dai corpora e da due studi di rating in un'analisi statistica condotta tramite modelli a effetti misti, risulta che le differenze nella prestazione dei partecipanti in due studi di decisione lessicale sono riconducibili a effetti di frequenza piuttosto che alla presenza di tratti lessicali categoriali

Verb generation for presurgical mapping: Gaining specificity

Verb generation is among the most frequently used tasks in presurgical mapping. Because this task involves many processes, the overall brain effects are not specific. While it is necessary to identify the whole network involving noun comprehension or semantic retrieval and lexical selection to produce the verb, isolation of those components is also crucial. Here, we present data from four patients undergoing presurgical brain mapping. The study implied a reanalysis of magnetoencephalography data with a recategorization of the used items. It aimed to extract the task component that relies on the inferior frontal gyrus (IFG). The task could be applied with higher specificity when targeting frontal areas. For that, we based item classification on the selection demands imposed by the noun. It is a robust finding that the IFG carries out this selection and that a quantitative index can be calculated for each noun, which depends on the selection effort (Proceedings of the National Academy of Sciences of the United States of America, 1997; 94(26):14792–14797, Proceedings of the National Academy of Sciences of the United States of America, 1998; 95(26):15855–15860). Data showed focality and specificity, with a correlation between this derived index and source activations in the inferior frontal gyrus for all patients. Strikingly, we detected when the right‐hemisphere homologue area was involved in the selection process in two patients showing reorganization or language right lateralization. The present data are a step towards a dissection of broad specific tasks frequently used in presurgical protocols

Is “Hit and Run” a Single Word? The Processing of Irreversible Binomials in Neglect Dyslexia

The present study is the first neuropsychological investigation into the problem of the mental representation and processing of irreversible binomials (IBs), i.e., word pairs linked by a conjunction (e.g., “hit and run,” “dead or alive”). In order to test their lexical status, the phenomenon of neglect dyslexia is explored. People with left-sided neglect dyslexia show a clear lexical effect: they can read IBs better (i.e., by dropping the leftmost words less frequently) when their components are presented in their correct order. This may be taken as an indication that they treat these constructions as lexical, not decomposable, elements. This finding therefore constitutes strong evidence that IBs tend to be stored in the mental lexicon as a whole and that this whole form is preferably addressed in the retrieval process

One can be some but some cannot be one: ERP correlates of numerosity incongruence are different for singular and plural

Humans can communicate information on numerosity by means of number words (e.g., one hundred, a couple), but also through Number morphology (e.g., through the singular vs the plural forms of a noun). Agreement violations involving Number morphology (e.g., *one apples) are well known to elicit specific ERP components such as the Left Anterior Negativity (LAN); yet, the relationship between a morphological Number value (e.g., singular vs plural) and its referential numerosity has rarely been considered in the literature. Moreover, even if agreement violations have been proven to be very useful, they do not typically characterise everyday language usage, thus narrowing the scope of the results. In this study we investigated Number morphology from a different perspective, by focusing on the ERP correlates of congruence and incongruence between a depicted numerosity and noun phrases. To this aim we designed a picture\u2013phrase matching paradigm in Italian. In each trial, a picture depicting one or four objects was followed by a grammatically well-formed phrase made up of a quantifier and a content noun inflected either in the singular or in the plural. When analysing ERP time-locked to the content noun, plural phrases after pictures presenting one object elicited a larger negativity, similar to a LAN effect. No significant congruence effect was found in the case of the phrases whose morphological Number value conveyed a numerosity of one. Our results suggest that: 1) incongruence elicits a LAN-like negativity independently from the grammaticality of the utterances and irrespectively of the P600 component; 2) the reference to a numerosity can be partially encoded in an incremental way when processing Number morphology; and, most importantly, 3) the processing of the morphological Number value of plural is different from that of singular as the former shows a narrower interpretability than the latter

Theta and alpha oscillations as signatures of internal and external attention to delayed intentions: A magnetoencephalography (MEG) study

Abstract Background Remembering to execute delayed intentions (i.e., prospective memory, PM) entails the allocation of internal and external attention. These processes are crucial for rehearsing PM intentions in memory and for monitoring the presence of the PM cue in the environment, respectively. Aim The study took advantage of the excellent spatial and temporal resolution of magnetoencephalography (MEG) to delineate the neural mechanisms of such memory and monitoring processes underlying PM. Method The spatio-temporal dynamic of theta and alpha oscillations were explored in 21 participants in 2 p.m. tasks and compared respect to a baseline condition (i.e., a lexical decision task with no PM instruction). The PM tasks varied for the load of internally-directed attention (Retrospective-load task) vs externally-directed attention (Monitoring-load task). Results Increase in theta activity was observed in the Retrospective-load task, and was particularly expressed in the regions of the Default Mode Network, such as in medial temporal regions, precuneus, posterior cingulate cortex and medial prefrontal cortex. By contrast, alpha decrease was the most relevant feature of the Monitoring-load task, and it was expressed over bilateral occipital, occipito-parietal and fronto-temporal regions, as well as over left dorsal fronto-parietal regions. Conclusions Theta and alpha oscillations are strictly associated with the direction of attention during the PM tasks. In particular, the theta increase is linked to internal attention necessary for maintaining the intention active in working memory, whereas the alpha decrease supports the external attention for detecting the PM cue in the environment

Stuttering as a matter of delay in neural activation: A combined TMS/EEG study

Objective: Brain dynamics in developmental stuttering (DS) are not well understood. The supplementary motor area (SMA) plays a crucial role, since it communicates with regions related to planning/execution of movements, and with sub-cortical regions involved in paced/voluntary acts (such as speech). We used TMS combined with EEG to shed light on connections in DS, stimulating the SMA. Methods: TMS/EEG was recorded in adult DS and fluent speakers (FS), stimulating the SMA during rest. TMS-evoked potentials and source distribution were evaluated. Results: Compared to FS, stutterers showed lower activity of neural sources in early time windows: 66\u2013 82 ms in SMA, and 91\u2013102 ms in the left inferior frontal cortex and left inferior parietal lobule. Stutterers, however, showed higher activations in later time windows (i.e. from 260\u2013460 ms), in temporal/premotor regions of the right hemisphere. Conclusions: These findings represent the functional counterpart to known white matter and cortico- basal-thalamo-cortical abnormalities in DS. They also explain how white matter abnormalities and cortico-basal-thalamo-cortical dysfunctions may be associated in DS. Finally, a mechanism is proposed in which compensatory activity of the non-dominant (right) hemisphere is recruited. Significance: DS may be a disorder of neural timing that appears to be delayed compared to FS; new mechanisms that support stuttering symptoms are inferred; the SMA may be a promising target for neuro-rehabilitation

Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration

(i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS

One can be some but some cannot be one: ERP correlates of numerosity incongruence are different for singular and plural

Humans can communicate information on numerosity by means of number words (e.g. one hundred, a couple), but also through Number morphology (e.g. through the singular vs. the plural forms of a noun). Agreement violations involving Number morphology (e.g. *one apples) are well known to elicit specific ERP components such as the Left Anterior Negativity (LAN); yet, the relationship between a morphological Number value (e.g. singular vs. plural) and its referential numerosity has been scantly considered in the literature. Moreover, even if agreement violations have been proved very useful, they do not typically characterise the everyday language usage, thus narrowing the scope of the results. In this study we investigated Number morphology from a different perspective, by focusing on the ERP correlates of congruence and incongruence between a depicted numerosity and noun phrases. To this aim we designed a picture–phrase matching paradigm in Italian. In each trial, a picture depicting one or four objects was followed by a grammatical phrase made up of a quantifier and a content noun inflected either in the singular or in the plural. When analysing ERP time-locked to the content noun, plural phrases after pictures presenting one object elicited a larger negativity, similar to a LAN effect. No significant congruence effect was found in the case of the phrases whose morphological Number value conveyed a numerosity of one. Considering the LAN as an index of morpho-syntactic incongruence, these results suggest that 1) LAN-like effects can be triggered independently from the grammaticality of the utterances and irrespective the P600 component; 2) the reference to a numerosity can be partially encoded in an incremental way when processing Number morphology; and, most importantly, 3) the processing of the morphological Number value of plural is different from that of singular as the former shows a narrower interpretability than the latter